Gene Therapy Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Angiotensins
Research findings from Ohio State University update understanding of angiotensins
November 12th, 2009
"Ras homolog gene family member A (RhoA)/Rho-kinase-mediated Ca2+ sensitization is a critical component of constrictor responses. The present study investigates how angiotensin II activates RhoA," scientists in the United States report. "Adenoviral vectors were used to manipulate the expression of regulator of G protein signaling (RGS) domain containing Rho-specific guanine exchange factors (RhoGEFs) and proline-rich tyrosine kinase 2 (PYK2), a nonreceptor tyrosine kinase, in primary rat vascular smooth muscle cells. As an evidence of RhoA activation, RhoA translocation and MYPT1 (the regulatory subunit of myosin light chain phosphatase) phosphorylation were analyzed by...
Source: Gene Therapy Weekly (2009-11-12)
|
