Gene Therapy
Studies from G.Y. Chen and co-researchers yield new data on gene therapy
Published in Gene Therapy Weekly, November 19th, 2009
"Human mesenchymal stem cells (hMSCs) can be genetically modified with viral vectors and hold promise as a cell source for regenerative medicine, yet how hMSCs respond to viral vector transduction remains poorly understood, leaving the safety concerns unaddressed. Here, we explored the responses of hMSCs against an emerging DNA viral vector, baculovirus (BV), and discovered that BV transduction perturbed the transcription of 816 genes associated with five signaling pathways," researchers in Hsinchu, Taiwan report.
"Surprisingly, Toll-like receptor-3 (TLR3), a receptor that generally recognizes double-stranded RNA, was apparently upregulated by BV transduction, as...
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Source: Gene Therapy Weekly (2009-11-19)
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