Vaccinia

New findings in vaccinia described from Food & Drug Administration

Published in Gene Therapy Weekly, November 19th, 2009

According to a study from the United States, "To find an alternative endpoint for the efficacy of antismallpox treatments, bioluminescence was measured in live BALB/c mice following lethal challenge with a recombinant WR vaccinia virus expressing luciferase. Intravenous vaccinia immunoglobulin treatments were used to confer protection on a proportion of animals."

"Using known lethality outcomes in 200 animals and total fluxes recorded daily in live animals, we performed univariate receiver operating characteristic (ROC) curve analysis to assess whether lethality can be predicted based on bioluminescence. Total fluxes in the spleens on day 3 and in the livers on day 5...

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Source: Gene Therapy Weekly (2009-11-19)

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