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Gene Therapy

Research from S.K. Pavelic and co-researchers in the area of gene therapy described

Published in Gene Therapy Weekly, November 26th, 2009

"p53 gene plays a crucial role in the response to therapy. Since it is inactivated in the majority of human cancers, it is strongly believed that the p53 mutations confer resistance to therapeutics," scientists in Zagreb, Croatia report.

"In this paper we analyzed the influence of two mechanistically diverse antitumor agents-cisplatin and methotrexate on the proliferation and cell cycle of two head and neck squamous cancer cell lines HEp-2 (wild type p53 gene, but HPV 18/E6-inactivated protein) and CAL 27 (mutated p53 gene), along with the influence of adenovirally mediated p53 overexpression in modulation of cisplatin and methoterexate effects, whereby subtoxic...

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