Gene Therapy
Study findings from University of Bristol provide new insights into gene therapy
Published in Gene Therapy Weekly, December 10th, 2009
According to recent research from Bristol, the United Kingdom, "Pontospinal noradrenergic neurons form a component of an endogenous analgesic system and represent a potential therapeutic target. We tested the principle that genetic manipulation of their excitability can alter nociception using an adenoviral vector (AVV-PRS-hKir(2.1)) containing a catecholaminergic-selective promoter (PRS) to retrogradely transduce and inhibit the noradrenergic neurons projecting to the lumbar dorsal horn through the expression of a potassium channel (hKir(2.1))."
"Expression of hKir(2.1) in catecholaminergic PC12 cells hyperpolarized the membrane potential and produced a...
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Source: Gene Therapy Weekly (2009-12-10)
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