HIV/AIDS

Reports from H.W. Mao and colleagues advance knowledge in HIV/AIDS

Published in Gene Therapy Weekly, December 17th, 2009

According to recent research from the United States, "Human Immunodeficiency Virus (HIV) is a global threat to public health. Current therapies that directly target the virus often are rendered ineffective due to the emergence of drug-resistant viral variants."

"An emerging concept to combat drug resistance is the idea of targeting host mechanisms that are essential for the propagation of the virus, but have a minimal cellular effect. Herein, using Random Homozygous Gene Perturbation (RHGP), we have identified cellular targets that allow human MT4 cells to survive otherwise lethal infection by a wild type HIV-1(NL4-3). These gene targets were validated by the...

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Source: Gene Therapy Weekly (2009-12-17)

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