Paclitaxel Therapy

Researchers from University of Incheon publish findings in paclitaxel therapy

Published in Gene Therapy Weekly, December 31st, 2009

"We previously demonstrated that the downregulation of Raf-1 kinase may contribute to the development of acquired resistance in paclitaxel-resistant cells. In this study, we determine whether the sensitivities of parental and its v-Ha-ras-transformed NIH 3T3 cells to paclitaxel were dependent on Raf-1 kinase activity," scientists writing in the journal Molecular and Cellular Biochemistry report.

"Paclitaxel sensitivity of v-Ha-ras-transformed cells was found to be significantly higher than that of its parental cells. Paclitaxel transiently increased Raf-1 kinase activity in v-Ha-ras-transformed cells while showing no effect on its parental cells, suggesting that...

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Source: Gene Therapy Weekly (2009-12-31)

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