Gene Therapy

Studies conducted at D. Madsen et al on gene therapy recently published

Published in Gene Therapy Weekly, December 31st, 2009

"Adeno-associated virus serotype 2 (AAV-2) has been developed as a gene therapy vector. Antibody and cell-mediated immune responses to AAV-2 or AAV-2-transfected cells may confound the therapeutic use of such vectors in clinical practice," investigators in Maynooth, Ireland report.

"In one of the most detailed examinations of AAV-2 immunity in humans to date, cell-mediated and humoral immune responses to AAV-2 were characterized from a panel of healthy blood donors. The extent of AAV-2-specific antibody in humans was determined by examination of circulating AAV-2-specific total IgG levels in plasma from 45 normal donors. Forty-one donors were seropositive and responses...

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Source: Gene Therapy Weekly (2009-12-31)

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