Gene Therapy
Scientists at Southwestern Medical Center target gene therapy
Published in Gene Therapy Weekly, January 7th, 2010
Current study results from the report, 'Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib,' have been published. According to recent research published in the journal Leukemia & Lymphoma, "Dasatinib, a dual Src/Abl tyrosine kinase inhibitor, has significant antileukemic effects against various imatinib mesylate-resistant BCR/ABL mutants. Despite well-documented inhibitory effects of dasatinib on BCR/ABL kinase, the exact downstream cellular events leading to generation of its potent antileukemic effects remain to be defined."
"We provide evidence that p38 Map kinase (MAPK) pathway is activated leading to increased...
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Source: Gene Therapy Weekly (2010-01-07)
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