Published in Gene Therapy Weekly, January 7th, 2010
"PI3K signaling plays a pivotal role in intracellular signal transduction pathways involved in cell growth, cellular transformation, and tumorigenesis. To specifically inhibit PI3K activity in colorectal cancer cells, we constructed a siRNA against the PI3K regulatory subunit p85 alpha and transfected it into LoVo and SW480 cells. In the present Study, treatment of colorectal cancer cells with PI3K p85 alpha-specific siRNA inhibited cell...
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