Oncolytic Adenoviruses Gene Therapy

Studies from J.J. Rojas and co-researchers yield new data on oncolytic adenoviruses gene therapy

Published in Gene Therapy Weekly, January 7th, 2010

Fresh data on oncolytic adenoviruses are presented in the report 'A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses.' According to recent research from Barcelona, Spain, "The E2F-1 promoter has been used to confer tumor-selective E1A expression in oncolytic adenoviruses. Tumor specificity is mainly conferred by a unique structure of E2F-responsive sites organized in palindromes."

"Binding of the E2F-pRb complex to these palindromes results in repression of transcription in normal cells. Owing to deregulation of the Rb/p16 pathway in tumor cells, binding of free E2F activates transcription and initiates an autoactivation loop...

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Source: Gene Therapy Weekly (2010-01-07)

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