Gene Therapy

Research from S.J. Zhang and co-authors provides new data about gene therapy

Published in Gene Therapy Weekly, January 7th, 2010

According to recent research published in the journal Plos Genetics, "Synaptic activity can boost neuroprotection through a mechanism that requires synapse-to-nucleus communication and calcium signals in the cell nucleus. Here we show that in hippocampal neurons nuclear calcium is one of the most potent signals in neuronal gene expression."

"The induction or repression of 185 neuronal activity-regulated genes is dependent upon nuclear calcium signaling. The nuclear calcium-regulated gene pool contains a genomic program that mediates synaptic activity-induced, acquired neuroprotection. The core set of neuroprotective genes consists of 9 principal components,...

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Source: Gene Therapy Weekly (2010-01-07)

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