Angiotensins

Scientists at University of California publish research in angiotensins

Published in Gene Therapy Weekly, January 21st, 2010

"Folate supplementation improves endothelial function in patients with hyperhomocysteinemia. Mechanistic insights into potential benefits of folate on vascular function in general population however, remain mysterious," scientists writing in the Journal of Molecular and Cellular Cardiology report.

"Expression of dihydrofolate reductase (DHFR) was markedly increased by folic acid (FA, 50 mu mol/L, 24 h) treatment in endothelial cells. Tetrahydrofolate (THF) is formed after incubation of purified DHFR or cellular extracts with 50 mu mol/L of substrate dihydrofolic acid. THF could then be detected and quantified by high performance liquid chromatography (HPLC) with...

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Source: Gene Therapy Weekly (2010-01-21)

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