Gene Therapy

Reports from National Institute of Dental and Craniofacial Research advance knowledge in gene therapy

Published in Gene Therapy Weekly, January 21st, 2010

Research findings, 'AAV5-mediated gene transfer to the parotid glands of non-human primates,' are discussed in a new report. "Salivary glands are potentially useful target sites for multiple clinical applications of gene transfer. Previously, we have shown that serotype 2 adeno-associated viral (AAV2) vectors lead to stable gene transfer in the parotid glands of rhesus macaques," scientists in the United States report.

"As AAV5 vectors result in considerably greater transgene expression in murine salivary glands than do AAV2 vectors, herein we have examined the use of AAV5 vectors in macaques at two different doses (n=3 per group; 10(10) or 3 x 10(11) particles per...

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Source: Gene Therapy Weekly (2010-01-21)

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