Gene Therapy
Studies conducted at Silpakorn University on gene therapy recently published
Published in Gene Therapy Weekly, January 28th, 2010
According to recent research published in the International Journal of Pharmaceutics, "The purpose of this study was to investigate the potential of nuclear localization signal (NLS) ''KPKKKRKV'' to mediate the in vitro transfection efficiency of chitosan (CS)/DNA complexes, aiming at its use in gene therapy applications. In the preparation of CS/DNA complexes containing NLS, peptide with NLS was directly incorporated without covalent conjugation to pDNA or chitosan."
"The gene transfer efficiency of CS/DNA complexes with and without NLS was evaluated in the human cervical carcinoma cell line (Hela cells). The CS/DNA complex containing NLS increased transfection...
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Source: Gene Therapy Weekly (2010-01-28)
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