Gene Therapy
Study results from R. Gabriel and colleagues in the area of gene therapy published
Published in Gene Therapy Weekly, January 28th, 2010
According to recent research from Heidelberg, Germany, "Retroviral vectors have induced subtle clonal skewing in many gene therapy patients and severe clonal proliferation and leukemia in some of them, emphasizing the need for comprehensive integration site analyses to assess the biosafety and genomic pharmacokinetics of vectors and clonal fate of gene-modified cells in vivo. Integration site analyses such as linear amplification-mediated PCR (LAM-PCR) require a restriction digest generating unevenly small fragments of the genome."
"Here we show that each restriction motif allows for identification of only a fraction of all genomic integrants, hampering the...
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Source: Gene Therapy Weekly (2010-01-28)
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