Bone Morphogenetic Protein

Korea University reports research in bone morphogenetic protein

Published in Gene Therapy Weekly, February 4th, 2010

"Up-regulation of bone morphogenetic proteins (BMPs) and their receptors by tumor is all important hallmark in cancer progression, as it contributes through autocrine and paracrine mechanisms to tumor development, invasion, and metastasis. Generally, increased motility and invasion are positively correlated with the epithelial-mesenchymal transition (EMT)," scientists writing in the journal Experimental Cell Research report.

"The purpose of the present study was to determine whether BMP-2 signaling to induce gastric cancer cells to undergo EMT-mediated invasion might pass through the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Herein we showed that gastric...

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Source: Gene Therapy Weekly (2010-02-04)

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