Spinal Cord Injury
Study results from Yonsei University, Medical Department broaden understanding of spinal cord injury
Published in Gene Therapy Weekly, February 4th, 2010
"An in vitro neural hypoxia model and rat spinal cord injury (SCI) model were used to assess the regulation effect of a reporter or therapeutic gene expression by an oxygen-dependent degradation (ODD) domain in a hypoxia-inducible gene expression system with or without the erythropoietin (EPO) enhancer. To increase vascular endothelial growth factor (VEGF) gene expression in SCI lesions but avoid unwanted overexpression of VEGF in normal sites, we developed a hypoxia-inducible gene expression system consisting of the EPO enhancer upstream of the SV promoter and an ODD domain C-terminally fused to VEGF," scientists in Seoul, South Korea report.
"Summary of Background...
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Source: Gene Therapy Weekly (2010-02-04)
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