Gene Therapy

New findings from University of Michigan in the area of gene therapy published

Published in Gene Therapy Weekly, February 4th, 2010

"Because bone reconstruction in irradiated sites is less than ideal, we applied a regenerative gene therapy method in which a cell-signaling virus was localized to biomaterial scaffolds to regenerate wounds compromised by radiation therapy. Critical-sized defects were created in rat calvariae previously treated with radiation," scientists writing in the Journal of Dental Research report.

"Gelatin scaffolds containing lyophilized adenovirus encoding BMP-2 (AdBMP-2) or freely suspended AdBMP-2 were transplanted. Lyophilized AdBMP-2 significantly improved bone quality and quantity over free AdBMP-2. Bone mineral density was reduced after radiotherapy. Histological...

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Source: Gene Therapy Weekly (2010-02-04)

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