Gastric Cancer

New gastric cancer study findings recently were reported by J. Yao and co-researchers

Published in Gene Therapy Weekly, February 11th, 2010

"The role of Notch-1 in human gastric carcinoma, one of the most common carcinomas of the human digestive tract, remains poorly characterised. Here, we investigated the effect and mechanism of Notch-1 activation on TNF alpha-induced apoptosis of human gastric carcinoma BGC-823 cells," scientists writing in the journal Digestive and Liver Disease report.

"Cell viabililty was measured by MTT assay. Apoptosis was detected by flow cytometry assay. Notch-1, Hes-1, caspase-3 p20 and NF-kappa B p65 expressions were assayed by Western blotting. NF-kappa B activation was tested by electrophoretic mobility shift assay (EMSA), and caspase-3 activation was tested by...

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Source: Gene Therapy Weekly (2010-02-11)

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