Anxiety Disorders

Data from A. Bahi et al provide new insights into anxiety disorders

Published in Gene Therapy Weekly, February 11th, 2010

According to recent research from the United States, "Organ transplant patients receive chronic administration of the calcineurin inhibitor cyclosporin-A (CsA) and demonstrate increased incidence of mood disorders. Significant calcineurin expression can be observed with immunohistochemistry in the amygdala, a brain area important for behaviors related to mood disorders and anxiety."

"It is therefore important to determine whether chronic blockade of calcineurin might contribute to symptoms of anxiety and depression in these patients. Pharmacological CsA and viral-mediated gene transfer (adeno-associated viral expression of short hairpin RNA [AAV-shRNA]) approaches were...

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Source: Gene Therapy Weekly (2010-02-11)

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