Alzheimer Disease

Study results from University of Rochester in the area of Alzheimer disease published

Published in Gene Therapy Weekly, February 18th, 2010

"Amyloid-beta (A beta) has been identified as a key component in Alzheimer's disease (AD). Significant in vitro and human pathological data suggest that intraneuronal accumulation of A beta peptides plays an early role in the neurodegenerative cascade," researchers in the United States report.

"We hypothesized that targeting an antibody-based therapeutic to specifically abrogate intracellular A beta accumulation could prevent or slow disease onset. A beta 42-specific intracellular antibodies (intrabodies) with and without an intracellular trafficking signal were engineered from a previously characterized single-chain variable fragment (scFv) antibody. The intrabodies,...

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Source: Gene Therapy Weekly (2010-02-18)

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