Angiogenesis

New findings from INSERM describe advances in angiogenesis

Published in Gene Therapy Weekly, February 18th, 2010

"Due to the lack of an adequate conventional therapy against lower limb ischemia, gene transfer for therapeutic angiogenesis is seen as an attractive alternative. However, the possibility of side effects, due to the expression of large amounts of angiogenic factors, justifies the design of devices that express synergistic molecules in low controlled doses," researchers in Toulouse, France report.

"We have developed an internal ribosome entry site (IRES)-based bicistronic vector expressing two angiogenic molecules, fibroblast growth factor 2 (FGF2), and Cyr61. Through electrotransfer into the ApoE(-/-) mice hindlimb ischemic muscle model, we show that the IRES-based...

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Source: Gene Therapy Weekly (2010-02-18)

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