Life Sciences

Research from D. Fagegaltier et al broadens understanding of life sciences

Published in Gene Therapy Weekly, February 18th, 2010

"A new class of small RNAs (endo-siRNAs) produced from endogenous double-stranded RNA (dsRNA) precursors was recently shown to mediate transposable element (TE) silencing in the Drosophila soma. These endo-siRNAs might play a role in heterochromatin formation, as has been shown in S. pombe for siRNAs derived from repetitive sequences in chromosome pericentromeres," scientists in the United States report.

"To address this possibility, we used the viral suppressors of RNA silencing B2 and P19. These proteins normally counteract the RNAi host defense by blocking the biogenesis or activity of virus-derived siRNAs. We hypothesized that both proteins would similarly block...

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Source: Gene Therapy Weekly (2010-02-18)

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