Apoptosis

New apoptosis findings from Shandong University described

Published in Gene Therapy Weekly, February 18th, 2010

According to recent research published in the journal Clinical and Experimental Pharmacology and Physiology, "1. C/EBP homologueueueous protein (CHOP), an endoplasmic reticulum (ER) stress-inducible protein, has a critical role in regulation of the cell cycle and apoptosis by forming heterodimers with other C/EBP proteins."

"However, how CHOP function is regulated remains to be determined. The human homologue of Drosophila tribbles (TRIB3) is associated with CHOP and is upregulated by oxidized low-density lipoprotein (ox-LDL). The aim of the present study was to investigate the role of CHOP in ox-LDL-induced TRIB3 expression in macrophages. 2. Human...

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Source: Gene Therapy Weekly (2010-02-18)

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