Antisense Technology
Reports summarize antisense technology research from University of Copenhagen
Published in Gene Therapy Weekly, February 18th, 2010
"The Her-2 receptor coded for by the proto-oncogenic erbB-2 gene is a clinically validated target for treatment of a significant genetic subclass of breast cancers, and Her-2 is also overexpressed or mutated in a range of other cancers. In an approach to exploit antisense mediated splicing interference as a means of manipulating erbB-2 expression in a therapeutically relevant fashion, we have studied the effect on mRNA splicing of a series of peptide nucleic acid (PNA) oligomers targeting specific intron-exon junctions in the erbB-2 pre-mRNA," investigators in Copenhagen, Denmark report.
"In particular, we are interested in identifying PNA oligomers that specifically...
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Source: Gene Therapy Weekly (2010-02-18)
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