Gene Therapy
New gene therapy study findings have been published by scientists at University of Iowa
Published in Gene Therapy Weekly, February 25th, 2010
"We report, for the first time, on the preparation, characterization and in vitro testing of poly(D,L-lactide-co-glycolide) (PLGA) microparticles loaded with poly-amidoamine (PAMAM)-plasmid DNA (pDNA) dendriplexes. Loading of pDNA into the PLGA microparticles increased by 150% when pDNA was first complexed with PAMAM dendrimers relative to loading of pDNA alone," scientists writing in the Journal of Pharmaceutical Sciences report.
"Scanning electron microscopy (SEM) showed that the presence of PAMAM dendrimers in the PLGA microparticles created porous features and indentations on the surface of the microparticles. Loading PLGA microparticles with PAMAM-pDNA...
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Source: Gene Therapy Weekly (2010-02-25)
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