Genetics
New research on genetics from University of Sheffield, Institute for Cancer Studies summarized
Published in Gene Therapy Weekly, February 25th, 2010
A new study, 'Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination,' is now available. According to recent research from Sheffield, the United Kingdom, "The feasibility of introducing point mutations in vivo using single-stranded DNA oligonucleotides (ssON) has been demonstrated but the efficiency and mechanism remain elusive and potential side effects have not been fully evaluated. Understanding the mechanism behind this potential therapy may help its development."
"Here, we demonstrate the specific repair of an endogenous non-functional hprt gene by a ssON in mammalian cells,...
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Source: Gene Therapy Weekly (2010-02-25)
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