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Vaccinia

Findings from San Raffaele Scientific Institute broaden understanding of vaccinia

Published in Gene Therapy Weekly, February 25th, 2010

Data detailed in 'The combination of marker gene swapping and fluorescence-activated cell sorting improves the efficiency of recombinant modified vaccinia virus Ankara vaccine production for human use' have been presented. "Modified vaccinia virus Ankara (MVA) is employed as a human vaccine vector for the high expression of heterologous genes and the lack of replication in mammalian cells. This study demonstrates that cells infected by recombinant viruses can be obtained by fluorescence-activated cell sorting," scientists writing in the Journal of Virological Methods report.

"Recombinant viruses are generated by a swapping event between a red fluorescent protein...

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