Glioblastoma Gene Therapy
Researchers from Tianjin Medical University, Neurological Institute describe findings in glioblastoma gene therapy
Published in Gene Therapy Weekly, February 25th, 2010
Current study results from the report, 'Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status,' have been published. "MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that regulate gene expression after transcription. Aberrant expression of miRNAs has been shown to be involved in tumorigenesis," scientists writing in the journal Laboratory Investigation report.
"We showed that miR-21 was one of the most frequently overexpressed miRNA in human glioblastoma (GBM) cell lines. To explore whether miR-21 can serve as a therapeutic target for glioblastoma, we downregulated miR-21...
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Source: Gene Therapy Weekly (2010-02-25)
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