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Gene Therapy

Researchers from University of Iowa, Carver College of Medicine describe findings in gene therapy

Published in Gene Therapy Weekly, March 11th, 2010

Investigators publish new data in the report 'Integrase-defective lentiviral vectors: progress and applications.' "Lentiviral vectors (LVs) offer the advantages of a large packaging capacity, broad cell tropism or specific cell-type targeting through pseudotyping, and long-term expression from integrated gene cassettes. However, transgene integration carries a risk of disrupting gene expression through insertional mutagenesis and may not be required for all applications," scientists in the United States report.

"A non-integrating LV may be beneficial in cases in which transient gene expression is desired. Several recent publications outline the development and initial...

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