Gene Therapy

Findings from A.J. Mahonen and co-researchers advance knowledge in gene therapy

Published in Gene Therapy Weekly, March 18th, 2010

According to a study from Kuopio, Finland, "Baculoviruses can express transgenes under mammalian promoters in a wide range of vertebrate cells. However, the success of transgene expression is dependent on both the appropriate cell type and culture conditions."

"We studied the mechanism behind the substantial effect of the cell culture medium on efficiency of the baculovirus transduction in different cell lines. We tested six cell Culture mediums: the highest transduction efficiency was detected in the presence of RPMI 1640 medium. Vimentin, a major component of type III intermediate filaments, was reorganized in the optimized medium, which associated with enhanced...

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Source: Gene Therapy Weekly (2010-03-18)

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