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Gene Therapy

Data on gene therapy reported by researchers at Shanghai Jiao Tong University

Published in Gene Therapy Weekly, March 18th, 2010

Research findings, 'Synthesis and evaluation of phenylalanine-modified hyperbranched poly(amido amine)s as promising gene carriers,' are discussed in a new report. "Hyperbranched poly(amido amine) (HPAMAM), which is structurally analogous to PAMAM dendrimers, has been proposed to be an effective agent for gene delivery. The facile synthesis of HPAMAM with scalable productivity by one-pot polymerization of monomers of methyl acrylate (MA) and diethylenetriamine (DETA) has been set up previously," investigators in Shanghai, People's Republic of China report.

"In this study, the HPAMAM was further modified on the terminal amino groups with phenylalanine to various degrees...

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