Antisense Technology
Study results from University of Arizona update understanding of antisense technology
Published in Gene Therapy Weekly, March 25th, 2010
A report, 'Whole mount in situ hybridization detection of mRNAs using short LNA containing DNA oligonucleotide probes,' is newly published data in Rna. According to recent research from the United States, "In situ hybridization is widely used to visualize transcribed sequences in embryos, tissues, and cells. For whole mount detection of mRNAs in embryos, hybridization with an antisense RNA probe is followed by visual or fluorescence detection of target mRNAs."
"A limitation of this approach is that a cDNA template of the target RNA must be obtained in order to generate the antisense RNA probe. Here we investigate the use of short (12-24 nucleotides) locked...
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Source: Gene Therapy Weekly (2010-03-25)
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