RNA Research
Reports on RNA research findings from University of Sherbrooke provide new insights
Published in Gene Therapy Weekly, April 1st, 2010
A new study, 'TAF6delta orchestrates an apoptotic transcriptome profile and interacts functionally with p53,' is now available. According to a study from Sherbrooke, Canada, "TFIID is a multiprotein complex that plays a pivotal role in the regulation of RNA polymerase II (Pol II) transcription owing to its core promoter recognition and co-activator functions. TAF6 is a core TFIID subunit whose splice variants include the major TAF6alpha isoform that is ubiquitously expressed, and the inducible TAF6delta."
"In contrast to TAF6alpha, TAF6delta is a pro-apoptotic isoform with a 10 amino acid deletion in its histone fold domain that abolishes its interaction with TAF9....
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Source: Gene Therapy Weekly (2010-04-01)
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