Genetics
Research results from K. Kandavelou and co-authors update knowledge of genetics
Published in Gene Therapy Weekly, April 8th, 2010
"Targeted introduction of a double-stranded break (DSB) using designer zinc finger nucleases (ZFNs) in mammalian cells greatly enhances gene targeting - homologous recombination (HR) at a chosen endogenous target gene, which otherwise is limited by low spontaneous rate of HR. Here, we report that efficient ZFN-mediated gene correction occurs at a transduced, transcriptionally active, mutant GFP locus by homology-directed repair, and that efficient mutagenesis by non-homologous end joining (NHEJ) occurs at the endogenous, transcriptionally silent, CCR5 locus in HEK293 Flp-In cells, using designed 3- and 4- finger ZFNs," scientists writing in the journal Biochemical and Biophysical...
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Source: Gene Therapy Weekly (2010-04-08)
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