Alzheimer Disease

New Alzheimer disease study results reported from University of Paris

Published in Gene Therapy Weekly, April 8th, 2010

"The development of Alzheimer's disease (AD) is closely connected with cholesterol metabolism. Cholesterol increases the production and deposition of amyloid-beta (A beta) peptides that result in the formation of amyloid plaques, a hallmark of the pathology," investigators in Paris, France report.

"In the brain, cholesterol is synthesized in situ but cannot be degraded nor cross the blood-brain barrier. The major exportable form of brain cholesterol is 24S-hydroxycholesterol, an oxysterol generated by the neuronal cholesterol 24-hydroxylase encoded by the CYP46A1 gene. We report that the injection of adeno-associated vector (AAV) encoding CYP46A1 in the cortex and...

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Source: Gene Therapy Weekly (2010-04-08)

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