Adenovirus
Researchers from Kanazawa University, Division of Pharmaceutical Sciences publish new studies and findings in the area of adenovirus
Published in Gene Therapy Weekly, April 8th, 2010
A report, 'An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and gamma-glutamylcysteine synthetase knockdown cells,' is newly published data in Toxicology In Vitro. According to recent research from Kanazawa, Japan, "Drug-induced hepatotoxicity is often caused by CYP-dependent activation of the drugs into reactive metabolites. CYP3A4 is one of the main isoforms involved in the metabolic activation of drugs."
"In this study, an adenovirus vector expressing CYP3A4 (AdCYP3A4) was constructed. After 3days infection of AdCYP3A4, the testosterone 6beta-hydroxylase activity reached to 325pmol/min/mg protein in H4IIE (rat hepatoma) cells....
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Source: Gene Therapy Weekly (2010-04-08)
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