Colon Cancer

Reports by C. Kaiser and co-researchers describe recent advances in colon cancer

Published in Gene Therapy Weekly, April 15th, 2010

"The tumor suppressor gene, SMAD4, is mutated in approximately 30% of colon cancers. To identify compounds with enhanced potency on cells with a SMAD4-negative context, we combined genomic and cheminformatic analyses of publicly available data relating to the colon cancer cell lines within the NCI60 panel," scientists in the United States report.

"Two groups of cell lines were identified with either wild-type or negative SMAD4 status. A cheminformatic analysis of the NCI60 screening data was carried out, which led to the identification of 14 compounds that preferentially inhibited cell growth of the SMAD4-negative cell lines. Using cell viability assays, the effect of...

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Source: Gene Therapy Weekly (2010-04-15)

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