Gene Therapy

New gene therapy research from Osaka University outlined

Published in Gene Therapy Weekly, April 15th, 2010

According to recent research published in the journal Transplant International, "Porcine endogenous retrovirus (PERV) is a major problem associated with successful clinical xenotransplantation. In our previous study, reducing the high mannose type of N-glycan content proved to be very effective in downregulating PERV infectivity."

"In this study, dolichyl-phosphate mannosyltransferase (D-P-M), an enzyme related to the early stages of N-linked sugar synthesis was studied. The pig cDNA of the encoding D-P-M was newly isolated. The RNA interference (siRNA) for the D-P-M was applied and transfected to PEC(Z)/PB cells, a pig endothelial cell line with the Lac Z gene...

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Source: Gene Therapy Weekly (2010-04-15)

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