Gene Therapy
Scientists at Wake Forest University, Department of Pathology discuss research in gene therapy
Published in Gene Therapy Weekly, April 15th, 2010
Current study results from the report, 'Alternative splicing attenuates transgenic expression directed by the apolipoprotein E promoter-enhancer based expression vector pLIV11,' have been published. According to recent research from the United States, "The plasmid vector pLIV11 is used commonly to achieve liver-specific expression of genes of interest in transgenic mice and rabbits. Expression is driven by the human apolipoprotein (apo)E 5' proximal promoter, which includes 5 kb of upstream sequence, exon 1, intron 1, and 5 bp of exon 2."
"A 3.8 kb 3' hepatic control region, derived from a region approximately 18 kb downstream of the apoE gene, enhances liver-specific...
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Source: Gene Therapy Weekly (2010-04-15)
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