Immunization

Study results from Slotervaart Hospital update understanding of immunization

Published in Gene Therapy Weekly, April 15th, 2010

According to recent research from Netherlands, "Nanoparticle-formulated DNA vaccines hold promise for the design of in vivo vaccination platforms that target defined cell types in human skin. A variety of DNA formulations, mainly based on cationic liposomes or polymers, has been investigated to improve transfection efficiency in in vitro assays."

"Here we demonstrate that formulation of DNA into both liposomal and polymeric cationic nanoparticles completely blocks vaccination-induced antigen expression in mice and ex vivo human skin. Furthermore, this detrimental effect of cationic nanoparticle formulation is associated with an essentially complete block in vaccine...

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Source: Gene Therapy Weekly (2010-04-15)

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