Life Sciences
Data on life sciences discussed by researchers at Harvard University
Published in Gene Therapy Weekly, April 22nd, 2010
A report, 'RPL41, a small ribosomal peptide deregulated in tumors, is essential for mitosis and centrosome integrity,' is newly published data in Neoplasia. According to a study from the United States, "Ribosomal large subunit protein RPL41 is a basic (positively charged) peptide consisting of only 25 amino acids. An antisense-based functional screening revealed that the down-regulation of RPL41 led to an anchorage-independent growth of NIH3T3 cells in soft agar plates."
"RPL41 depletion with gene-specific small interfering RNA also resulted in malignant transformation of NIH3T3 cells including increased tumor growth in mice. RPL41 deletion was detected in 59% of...
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Source: Gene Therapy Weekly (2010-04-22)
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