Allograft Vasculopathy

Reports outline allograft vasculopathy study results from University of Texas

Published in Gene Therapy Weekly, April 22nd, 2010

According to recent research from the United States, "Cardiac transplant arteriosclerosis or cardiac allograft vasculopathy remains the leading cause of graft failure and patient death in heart transplant recipients. Endothelial cell injury is crucial in the development of human atherosclerosis and may play a role in allograft vasculopathy."

"Glutathione-S-transferase (GST) is known to protect endothelial cells from damage by oxidants and toxins. However, the contribution of human GST A4-4 (hGSTA4-4) to vascular cell injury and consequent transplant arteriosclerosis is unknown. A recombinant adenoviral vector containing hGSTA4-4 gene was constructed and delivered to...

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Source: Gene Therapy Weekly (2010-04-22)

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