Gene Therapy
Research on gene therapy reported by scientists at Johns Hopkins University, Department of Biomedical Engineering
Published in Gene Therapy Weekly, April 22nd, 2010
Data detailed in 'Sites in the AAV5 capsid tolerant to deletions and tandem duplications' have been presented. According to a study from the United States, "Gene therapy vectors based on adeno-associated virus (AAV) have shown much promise in clinical trials for the treatment of a variety of diseases. However, the ability to manipulate and engineer the viral surface for enhanced efficiency is necessary to overcome such barriers as pre-existing immunity and transduction of non-target cells that currently limit AAV applications."
"Although single amino acid changes and peptide insertions at select sites have been explored previously, the tolerance of AAV to small...
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Source: Gene Therapy Weekly (2010-04-22)
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