Drug Resistance
Research from Zhejiang University has provided new data on drug resistance
Published in Gene Therapy Weekly, April 29th, 2010
According to a study from Hangzhou, People's Republic of China, "The use of antibiotic resistance genes in plasmids causes potential biosafety and clinical hazards, such as the possibility of horizontal spread of resistance genes or the rapid emergence of multidrug-resistant pathogens. This paper introduces a novel auxotrophy complementation system that allowed plasmids and host cells to be effectively selected and maintained without the use of antibiotics."
"An Escherichia coli strain carrying a defect in NAD de novo biosynthesis was constructed by knocking out the chromosomal quinolinic acid phosphoribosyltransferase (QAPRTase) gene. The resistance gene in the...
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Source: Gene Therapy Weekly (2010-04-29)
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