Apoptosis Gene Therapy
Findings in apoptosis gene therapy reported from University of Texas, M. D. Anderson Cancer Center
Published in Gene Therapy Weekly, May 6th, 2010
Investigators publish new data in the report 'Downmodulation of Bcl-2 sensitizes metastatic LNCaP-LN3 cells to undergo apoptosis via the intrinsic pathway.' According to a study from the United States, "We explored the mechanisms of apoptosis after Bcl-2 protein downmodulation in metastatic LNCaP-LN3 cells (LN3). LNCaP, LNCaP-Pro5 (Pro5) and LN3 cells were cultured in 5% charcoal-stripped serum (CSS) or in R1881 (synthetic androgen) and bicalutamide (synthetic anti-androgen) and growth inhibition was assessed."
"Expression levels of androgen receptor (AR) and Bcl-2 were determined. LN3 cells were transfected with small interfering RNA Bcl-2 (siRNA Bcl-2) or control...
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Source: Gene Therapy Weekly (2010-05-06)
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