Hormones

Studies from S. Kouidhi and co-researchers update current data on hormones

Published in Gene Therapy Weekly, May 6th, 2010

According to a study from Paris, France, "Thyroid hormone receptor (TR) and peroxisome proliferator-activated receptor gamma (PPAR gamma) co-regulate numerous peripheral metabolic responses. To examine potential crosstalk between PPAR gamma and TR beta in the hypothalamus, thyrotropin-releasing hormone (Trh) regulation in the newborn mouse hypothalamus was followed."

"QPCR showed PPAR gamma to be expressed in the hypothalamus at this developmental stage. Intracerebral injection of PPAR gamma agonists modified transcription from a TRH-luc construct introduced into the hypothalamus and increased serum thyroxine levels. Furthermore shRNA-based in vivo, PPAR gamma knockdown...

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Source: Gene Therapy Weekly (2010-05-06)

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