Macrophages
Research from Fudan University, Department of Physiology in macrophages provides new insights
Published in Gene Therapy Weekly, May 13th, 2010
Research findings, 'Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRalpha activation,' are discussed in a new report. According to recent research from Shanghai, People's Republic of China, "Accumulated mast cells in atherosclerotic plaques secrete a high level of tryptase that may participate in the pathogenesis of atherosclerotic disease by diverse pathways. However, the role of tryptase in the lipid metabolism of macrophages remains to be defined."
"In the present study, we found that the addition of tryptase into THP-1-derived macrophages increased both intracellular lipid accumulation and total cholesterol level. Tryptase...
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Source: Gene Therapy Weekly (2010-05-13)
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