Hepatic Stellate Cells
Studies from Mount Sinai School of Medicine in the area of hepatic stellate cells published
Published in Gene Therapy Weekly, May 13th, 2010
Data detailed in 'Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP)' have been presented. "Hepatic stellate cells (HSCs) store retinoids and triacylglycerols in cytoplasmic lipid droplets. Two prominent features of HSC activation in liver fibrosis are loss of lipid droplets along with increase of alpha-smooth muscle actin (alpha-SMA), but the link between these responses and HSC activation remains elusive," scientists in the United States report.
"In non-adipose cells, adipose differentiation-related protein (ADRP) coats lipid droplets and regulates their formation and lipolysis;...
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Source: Gene Therapy Weekly (2010-05-13)
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